Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 80
- 主要终点
- patient symptoms improvement(Standard questionare)
研究概览
简要总结
The purpose of this study is to determine whether Tamsolusin or Prazosin are effective in the treatment of female voiding dysfunction(BOO)
详细描述
Voiding dysfunction is not uncommon in Tabriz.About 20% of patients in female urology clinic of Tabriz university of medical sciences sufered from some degrees of voiding dysfunction (due to bladder imparement or bladder outlet obstruction).There is limited information about medical treatment of those patients. On the other hand alpha adrenergic blockers are the first choice medication in BENIGN PROSTATIC HYPERPLASIA. There is some new facts about destribution of alpha adrenergic blockers in female pelvic floor.The purpose of this study is to comparision whether Tamsolusin 0.4/daily or Prazosin 1 mg/daily are effective in the treatment of female voiding dysfunction(BOO)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Healthy females with voiding difficulty with MFR<12 and post void residual urine>50cc
排除标准
- •History of pelvic floor surgury during last 3 month
- •Any contraindication for Tamsolusin or prazosin
研究组 & 干预措施
1
taking Tamsulosin
干预措施: tamsolusin (Drug)
2
taking prasosin
干预措施: prazosin (Drug)
结局指标
主要结局
patient symptoms improvement(Standard questionare)
时间窗: every month untile 3 months
次要结局
- Urodynamics parameters improvement(three months later)