ACTRN12620000998943已完成未知
Modulation of bone/joint biomarkers, gut microbiota and inflammation status by synbiotics (pre and probiotics) and weight-bearing exercise in women with confirmed menopause
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 88
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 55 Years 至 80 Years（—）
- 性别
- Female
入选标准
- •Confirmed menopause [by an initial blood test (baseline screening) that includes checking of levels of follicle-stimulating hormone (FSH greater than or equal to 30 mIU/mL) and oestrogen] of at least 5 years based on no menstruation. Body Mass Index (BMI) between 17 and 35 kg/m².
排除标准
- •1.Use of hormone replacement therapy (HRT).
- •2.Biphosphonates in last 6 months.
- •3.Currently on estrogen, tamoxifen, Aromatase Inhibitors or other antiresorptive or anabolic treatment of osteoporosis
- •4.Liver function test or creatinine above the normal range, or any other history suggesting liver or kidney disease to be confirmed by the baseline screening.
- •5.Incidence of diabetes mellitus by using the questionnaire and baseline screening.
- •6.Subjects with an estimated BMD T-score lower than -2.5 or fragility fracture in the previous 6 months.
- •7.Antibiotics intake in the previous 6 months
- •8.Smoking and intake of alcohol > 2 units per day.
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