NCT02132962已完成不适用
Sarcopenia and Cirrhosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Turnover of phenylalanine and tyrosine in skeletal muscle tissue during amino acid infusion. Inflammatory markers. Protein signaling cascade.
研究概览
简要总结
The study investigates the effect of aminoacid infusion on proteinturnover in muscle from cirrhosis subjects, compared to healthy controls.
The hypothesis is that aminoacid infusion can attenuate the increase in proteindegradation that follows cirrhosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male subjects
- •Diagnosis of cirrhosis, Child-Pugh A, B, C.
排除标准
- •Acute illness within 3 weeks
- •Ascites collections within 10 days
- •Heart-, kidney, pulmonary disease. Cancer. Type 1 diabetes.
- •Active alkoholdrinking
结局指标
主要结局
Turnover of phenylalanine and tyrosine in skeletal muscle tissue during amino acid infusion. Inflammatory markers. Protein signaling cascade.
时间窗: 24 weeks
Using stable isotope tracer technique with infusion of phenylalanine and tyrosine tracer. Using ELISA technique. Using PCR and western blot technique.
次要结局
未报告次要终点
研究者
Anders Rasmussen Rinnov
MD, PhD
Rigshospitalet, Denmark
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD PatientsChronic Liver DiseaseNCT04246918Institute of Liver and Biliary Sciences, India60
Unknown
不适用
Effect of Branch Chain Amino Acid Therapy on Sarcopenia in Children With Chronic Liver Disease.SarcopeniaCirrhosis, LiverNCT05093218Institute of Liver and Biliary Sciences, India44
已完成
不适用
The investigation about bone metabolism and sarcopenia among chronic hepatitis C patients and the impacts of DAAs combination therapy.Chronic hepatitis CJPRN-UMIN000027717ippon Medical School Chiba Hokusoh Hospital204
进行中（未招募）
3 期
Treatment of Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child CLiver CirrhosisNCT03633279Dayanand Medical College and Hospital96
已完成
不适用
Metabonomic of Patients With Hepatitis B Cirrhosis Complicated With Sarcopenia.SarcopeniaNCT05041348The Affiliated Hospital of Qingdao University60