NCT00262574Unknown4 期
Phase 4 Study of Patients Receiving BNP or NTG (IV) During Angioplasty, Re-examined 24 Hours Later Using the Flow-mediated Brachial Artery Dilation Study, and Blood Assays for Pro BNP and ET1
适应症
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 500
- 试验地点
- 2
- 主要终点
- FMD
研究概览
简要总结
Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •coronary artery disease -
排除标准
- •CHF and/or reduced LV function, or renal failure with Creatinine >2mg%
结局指标
主要结局
FMD
时间窗: 3 years
次要结局
未报告次要终点
研究者
研究点 (2)
Loading locations...
相似试验
已完成
3 期
Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free FlowInternal Mammary Artery SyndromeVasodilationNCT06301880Damascus University46
已完成
4 期
The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass GraftingCoronary Artery BypassCardiopulmonary BypassNCT03251599Recep Tayyip Erdogan University78
Unknown
不适用
BNP and Vascular SurgeryGeneral AnesthesiaVascular SurgeryNatriuretic Peptide, BrainMetsPreoperative PeriodPostoperative PeriodAbdominal Aortic AneurysmNCT03926104University of Parma165
Unknown
早期 1 期
Anti-oxidant Therapy and Postoperative Cardiac Events (ACE) Trial, Preoperative Intervention in Vascular SurgeryMyocardial InjuryNCT03956017Minneapolis Veterans Affairs Medical Center341
招募中
1 期
Evaluation the effects of vasodilator (nitroglycerin-TNG) in Cardioplegic Solution myocardial ischemia in patients treated with coronary artery bypass graft surgery in Chamran Hospital, IsfahaCardiovascular surgery.Atherosclerotic heart disease of native coronary arteryI25.1IRCT20211225053517N1Esfahan University of Medical Sciences44
