A Population-based Cohort of Osteoarthritis: the Tsinghua University Tiantongyuan Community Osteoarthritis Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- Incidence of Osteoarthritis
研究概览
简要总结
The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.
详细描述
- To investigate the natural history of osteoarthritis (OA) in a large-sample cohort.
- To identify OA phenotypes and their relationship with clinical symptoms and functional impairment.
- To analyze metabolic factors (e.g., obesity, diabetes, and hypertension) as risk factors for OA onset and progression.
- To evaluate the association between radiographic changes and OA symptoms.
- To develop predictive models for OA progression and identify high-risk individuals for early intervention.
Design: This is a prospective cohort study. Participants: The study will recruit approximately 4,000 individuals aged 50 years and above. Participants will undergo baseline assessments, including demographic data collection, medical history, dietary evaluation, physical examination, blood sample collection, and radiographic imaging. Annual follow-ups will be conducted over 10 years to monitor OA progression and related risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 50 years and above
- •Long-term resident of the study area
- •Willing to participate and provide informed consent
排除标准
- •Hearing, speech, or mental impairments preventing effective communication
- •Unable to complete scheduled follow-up visits
- •Pregnant or planning pregnancy during the study period
- •Any other condition deemed unsuitable for participation by the researchers
结局指标
主要结局
Incidence of Osteoarthritis
时间窗: Annually for 10 years
The occurrence of clinically diagnosed osteoarthritis based on imaging and clinical symptoms during the follow-up period.
次要结局
- Five Times Sit-to-Stand Test (5TSTS)(Annually for 10 years)
- Radiographic Progression of Osteoarthritis(Annually for 10 years)
- Change in Joint Pain Severity (WOMAC Pain Subscale)(Annually for 10 years)
- Change in Physical Function (WOMAC Subscale)(Annually for 10 years)
- Change in Physical Function (SF-36 Physical Function Domain)(Annually for 10 years)
- Timed Up and Go Test (TUGT)(Annually for 10 years)
- Changes in Body Mass Index (BMI)(Annually for 10 years)
- Changes in Blood Pressure(Annually for 10 years)
- Changes in Fasting Glucose(Annually for 10 years)
- Changes in Total Cholesterol (TC)(Annually for 10 years)
- Changes in Low-Density Lipoprotein Cholesterol (LDL-C)(Annually for 10 years)
- Changes in High-Density Lipoprotein Cholesterol (HDL-C)(Annually for 10 years)
- Changes in Triglycerides (TG)(Annually for 10 years)