NCT01757743已完成不适用
Protein Distribution and Colloid Osmotic Pressure in Children With Volume and Pressure Loading Due to Congenital Heart Defects
Oslo University Hospital1 个研究点 分布在 1 个国家目标入组 41 人开始时间: 2013年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Interstitial colloid osmotic pressure
研究概览
简要总结
This project will evaluate fluid balance and oedema formation in children with the same congenital heart disease (Atrial Septal Defect) who will either go through heart surgery with the use of Cardio Pulmonary Bypass and hypothermia or through interventional catheterization. The investigators will measure interstitial colloid osmotic pressure, distribution of proteins and cytokines. The study hypothesis is that "Oedema developed during heart surgery is caused by reduced colloid osmotic pressure gradient through the capillary membrane".
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Months 至 10 Years(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The diagnosis of Atrial Septal Defect scheduled for closure
- •Informed consent
排除标准
- •Renal failure,
- •liver failure,
- •coexisting cardiac malformations
结局指标
主要结局
Interstitial colloid osmotic pressure
时间窗: During surgery or interventional closure
次要结局
未报告次要终点
研究者
Marianne Indrebo
MD Research fellow
Oslo University Hospital
研究点 (1)
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