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临床试验/NCT01757743
NCT01757743已完成不适用

Protein Distribution and Colloid Osmotic Pressure in Children With Volume and Pressure Loading Due to Congenital Heart Defects

Oslo University Hospital1 个研究点 分布在 1 个国家目标入组 41 人开始时间: 2013年2月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
41
试验地点
1
主要终点
Interstitial colloid osmotic pressure

研究概览

简要总结

This project will evaluate fluid balance and oedema formation in children with the same congenital heart disease (Atrial Septal Defect) who will either go through heart surgery with the use of Cardio Pulmonary Bypass and hypothermia or through interventional catheterization. The investigators will measure interstitial colloid osmotic pressure, distribution of proteins and cytokines. The study hypothesis is that "Oedema developed during heart surgery is caused by reduced colloid osmotic pressure gradient through the capillary membrane".

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
6 Months 至 10 Years(Child)
性别
All
接受健康志愿者

入选标准

  • The diagnosis of Atrial Septal Defect scheduled for closure
  • Informed consent

排除标准

  • Renal failure,
  • liver failure,
  • coexisting cardiac malformations

结局指标

主要结局

Interstitial colloid osmotic pressure

时间窗: During surgery or interventional closure

次要结局

未报告次要终点

研究者

发起方
Oslo University Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Marianne Indrebo

MD Research fellow

Oslo University Hospital

研究点 (1)

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