NCT03078504终止不适用
Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Blood Pressure Change
研究概览
简要总结
Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-89
- •Acute renal failure or end-stage renal disease necessitating CRRT
- •Admitted to the MICU service
- •If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
- •If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
- •If on IV fluids, stable dose of crystalloids <= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
- •Mean arterial pressure (MAP) >= 65
- •Arterial catheter present for continuous blood pressure monitoring
- •CRRT duration of 48 hours or less using NxStage System One dialysis system
- •successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability
- •no other procedures, blood products transfusion, or additional medication administration are anticipated during the study period
排除标准
- •listed for organ transplant
- •atrial fibrillation, other irregular heart rhythm, unstable arrhythmia
- •need for more than one intravenous vasopressor agent
- •intravenous vasopressor/inotropic agent other than norepinephrine (ie dobutamine, dopamine, vasopressin, epinephrine)
- •therapeutic anticoagulation being administered
- •known acute myocardial infarction as defined by elevated troponin along with a documented clinical diagnosis during current hospitalization
- •known acute stroke, intracerebral hemorrhage, intracranial mass effect, or elevated intracranial pressure within the last 30 days.
- •dialysis catheter malfunction and unable to maintain target blood flow rate
- •fluid removal (ultrafiltration) rate > 100mL/hour
结局指标
主要结局
Blood Pressure Change
时间窗: 10 minutes
Change in mean arterial pressure from period 1 to period 2
次要结局
未报告次要终点
研究者
Zafar Jamkhana, MD
Associate Professor
St. Louis University
研究点 (2)
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