NCT03356301已完成不适用
Study of the Remodeling of the Ascending Aorta During the Sports Season in Long Distance Triathletes Versus Controls
Central Hospital, Nancy, France2 个研究点 分布在 1 个国家目标入组 63 人开始时间: 2017年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 2
- 主要终点
- Aortic compliance in triathletes in mm2/mmHG
研究概览
简要总结
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •to be enrolled in a social security plan.
- •to have a BMI between 18,5 and 25 kg/m²
- •to have received full information on the organization of the research and having signed its informed consent
- •to have carried out a clinical screening adapted to the research
- •*** Triathlete group:
- •to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),
- •to participate in 2018 in a long distance triathlon, i. e. at least distance L
- •to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective
- •***Control group:
- •to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).
排除标准
- •Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
- •Cardiovascular history including Ii.e. known heart rhythm disorders
- •Chronic disease: diabetes, high blood pressure...
- •Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
- •Active smoking, even if occasional
- •Contraindication to MRI
结局指标
主要结局
Aortic compliance in triathletes in mm2/mmHG
时间窗: at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak)
aortic compliance = pulsed pressure-to-absolute variation of aortic surface ratio
次要结局
未报告次要终点
研究者
研究点 (2)
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