NCT03903549已完成1 期
A Positron Emission Tomography (PET) Study to Investigate [18F]D6-FP-DTBZ ([18F]P17-059) for Potential Use as a Radioligand for Vesicular Monoamine Transporter (VMAT2)
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Regional brain uptake of [18F]P17-057 in Parkinson patients compared healthy volunteers
研究概览
简要总结
This study investigates the initial safety profile of [18F]P17-059 in healthy volunteers including dosimetry determination, and compares regional brain uptake and kinetics of [18F]P17-059 in Parkinson's disease patients with regional brain uptake and kinetics of [18F]P17-059 in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Brain uptake and kinetics in Parkinson patients
Experimental
干预措施: [18F]P17-059 (Drug)
Brain uptake and kinetics in healthy volunteers
Experimental
干预措施: [18F]P17-059 (Drug)
Dosimetry in healthy volunteers
Experimental
干预措施: [18F]P17-059 (Drug)
结局指标
主要结局
Regional brain uptake of [18F]P17-057 in Parkinson patients compared healthy volunteers
时间窗: 0 - 90 minutes post injection
Quantitative estimates of \[18F\]P17-059 uptake in brain - SUV and non-displaceable Binding Potential
Cumulative organ [18F]P17-059 activity for estimates of radiation absorbed dose and effective dose
时间窗: 0 - 240 minutes post injection
Dosimetry
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
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