Evaluation of PACE4 Isoforms as Biomarkers in Thyroid Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Robert Day
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Expression pattern of the studied protein convertase
研究概览
简要总结
The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no fully reliable molecular marker for thyroid cancer have been described. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a biomarker.
详细描述
Patients that underwent thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and classified according to the pathological diagnosis. An immunohistochemistry technique, developed and calibrated for the specific protein convertase studied, will be undertaken. Results will be interpreted by a specialized pathologist.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men of women, aged 18-100 y.-o.
- •History of subtotal or total thyroidectomy at the "Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke" (CIUSSS de l'Estrie - CHUS) between January 2010 and May 2016.
排除标准
- •Refusal to participate to the study.
- •Unavailability of the formalin-fixed, paraffin-embedded tissues.
- •Uncertain pathological diagnosis.
结局指标
主要结局
Expression pattern of the studied protein convertase
时间窗: Trough study completion, an average of 1 year after the patients have been operated.
Horseradish peroxidase staining with specific antibodies.
次要结局
未报告次要终点