Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients Undergoing Colorectal Cancer Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- rectus femoris muscle thickness
研究概览
简要总结
After obtaining ethical approval, 42 patients with American Society of Anesthesiologists (ASA) scores I-III who were scheduled for surgery under general anesthesia were included in our prospective study. Patients were monitored in the preoperative preparation room in the operating room and frailty was assessed using the FRAIL scale and sarcopenia was assessed using the STAR ratio. The thickness of the rectus femoris and vastus intermedius muscles of the patients was measured and recorded by ultrasonography. Thigh lengths were measured and recorded. Rectus Femoris/Thigh Length (RF/B), Vastus Intermedius/Thigh Length (VI/B), and Total Muscle Thickness/Thigh Length (T/B) were calculated and recorded. Patients were followed up according to the Modified Aldrete Score after surgery in the anesthesia recovery unit, and the time to reach 9-10 points was recorded, and the time to leave the recovery unit was recorded. Postoperatively, complications were followed up according to the Clavien-Dindo Classification, and discharge times from the hospital were recorded.
详细描述
Frailty is a clinically identifiable state of heightened vulnerability resulting from age-related declines in physiological systems and functions, leading to impaired resilience to stressors. Frailty is highly prevalent among the elderly and is associated with an increased risk of falls, disability, hospitalization, and mortality. Magnetic resonance imaging (MRI) and computed tomography (CT) are considered the gold standard for sarcopenia diagnosisCT is also limited due to radiation exposure and similar logistical constraints. In contrast, ultrasonography (USG) is portable, cost-effective, and can be performed at the bedside without radiation exposure.
Using high-frequency ultrasound probes, peripheral muscle tissues and their dimensions can be rapidly assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients over 60 years of age who are undergoing colorectal malignancy surgery under general anesthesia
- •patients willing to participate in the study
- •Patients with ASA score I-III
排除标准
- •Patients with Parkinson's disease,
- •Alzheimer's disease,
- •history of cerebrovascular events,
- •neuromuscular disease,
- •cognitive dysfunction,
- •severe liver disease,
- •severe heart disease,
- •impaired cooperation due to kidney disease,
- •emergency and trauma patients,
- •patients with bilateral lower extremity amputations
结局指标
主要结局
rectus femoris muscle thickness
时间窗: 1 year
cm
sex
时间窗: 1 year
female, male
height
时间窗: 1 year
meter
age
时间窗: 1 year
years old
body weight
时间窗: 1. year
kg
educational status
时间窗: 1 year
primary school graduate, middle school graduate, high school graduate, university graduate
marital status
时间窗: 1 year
married, single, widowed
ASA score
时间窗: 1 year
American Society of Anesthesiologists' Classification (ASA 1,2,3,4,5)
vastus intermedius(VI) thickness
时间窗: 1 year
cm
rectus femoris-to-thigh length ratio
时间窗: 1 year
ratio
vastus intermedius-thigh length ratio
时间窗: 1 year
ratio
total muscle thickness to thigh length ratio
时间窗: 1 year
ratio
frailty score
时间窗: 1 year
0-NORMAL, 1-2 PRE-FRAİL, 3-5 FRAİL
recovery time from anesthesia
时间窗: 1 year
minutes
hospital discharge time
时间窗: 1 year
days
Modified Clavien-Dindo Classification
时间窗: 1 year
1, 2, 3A, 3B, 4A, 4B, 5
次要结局
未报告次要终点
研究者
Ferda YAMAN
Associate Professor
Eskisehir Osmangazi University