Examining the benefit of graduated compression stockings as an adjunct to low dose low molecular weight heparin in the prevention of venous thromboembolism in elective surgical inpatients identified as moderate or high risk for venous thromboembolism: A multi-centre randomised controlled trial

Imperial College London0 个研究点目标入组 1,905 人开始时间: 2016年1月27日最近更新: 2023年2月27日

适应症

试验速览

2017 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/28396238 protocol 2020 Results article in https://doi.org/10.1136/bmj.m1309 results (added 10/06/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33275096/ results (added 07/12/2020)

•Current inclusion criteria as of 26/04/2018:
•1. Aged 18 years or over (from Jan 2018 recruitment will be restricted to patients aged 65 years and above)
•2. Capacity to provide informed consent
•3. Elective surgical inpatients at a participating hospital
•4. Moderate or high risk of venous thromboembolism (VTE)
•Previous inclusion criteria:
•1. Aged 18 years or over
•2. Capacity to provide informed consent
•3. Elective surgical inpatients at a participating hopsital
•4. Moderate or high risk of venous thromboembolism (VTE)

•1. Contraindications to low molecular weight heparin (LMWH)
•2. Contraindications to graduated compression stockings (GCS), including peripheral arterial disease, stroke patients,
•individuals undergoing lower limb surgery
•3. Documented or known thrombophilia or thrombogenic disorder
•4. Individuals requiring therapeutic anticoagulation
•5. Previous venous thromboembolism (VTE)
•6. Patients having intermittent pneumatic compression (IPC) beyond theatre and recovery
•7. Patients requiring inferior vena cava (IVC) filter
•8. Pregnancy
•9. Patients requiring extended thromboprophylaxis
•10. Application of a cast or brace in theatre

发起方