The Effect of Magnesium Replacement Therapy in Altering the Course of Hypocalcaemia Post Total Thyroidectomy in Thyroid Cancer Patients

Dr Ahmed Serag0 个研究点目标入组 60 人开始时间: 2023年12月11日最近更新: 2024年3月4日

适应症

试验速览

暂无简介。

•Patients suffering from hypocalcaemia post total thyroidectomy at National Cancer Institute.
•At least one parathyroid gland must be preserved with normal PTH levels.
•Adults only will be included (age from 18 to 65 years).
•Preoperative serum calcium, magnesium, phosphorus and vitamin D levels are normal in all patients.

•Infants and children (age < 18 years)
•Elderly (age > 65 years)
•Pregnant women
•Cognitively impaired or mentally disabled subjects
•Patients with history of thyroid surgeries
•All parathyroid glands are lost during surgery
•Severe symptomatic hypocalcaemia needing to be treated with intravenous calcium for emergency expressed as seizures or tetanic convulsions including Trousseau`s sign and Chvostek`s sign (with cut-off point of calcium level < 7 mg/dl)
•Moderate and severe hypomagnesaemia (Mg level < 1.2 mg/dl) or Symptomatic hypomagnesaemia needing to be treated with intravenous magnesium for emergency (but in case of mild asymptomatic hypomagnesaemia in the treatment and the control group no special intervention or exclusion)
•Patients with renal impairment ( Creatinine clearance (Crcl) < 60ml/min )
•Patients with hepatic impairment (Alanine aminotransferase (ALT) > 50 IU/L , Aspartate aminotransaminase (AST) > 40 IU/L and Total bilirubin > 1.2 mg/dl )
•Patients taking any medication that would affect calcium levels such as, Thiazide diuretics, lithium, rifampicin, phenytoin, Bisphosphonates, Dietary supplements containing calcium and vitamins affecting calcium level such as vitamin D, etc.
•patients with other types of cancer other than thyroid cancer (e.g. any metastasis).

发起方

Dr Ahmed Serag