Can Tea Prevent Impairments in Vascular Function and Insulin Sensitivity Induced by 7-days Physical Inactivity and Overfeeding in Healthy Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Insulin sensitivity
研究概览
简要总结
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) in healthy male volunteers, and examine whether daily intake of tea can prevent such changes.
详细描述
The aim of this study is to explore the impact of a 7-day 'unhealthy' lifestyle that combines physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) on peripheral (conduit artery and skin microvessels) and cerebrovascular function and insulin sensitivity in healthy male participants. Moreover, the investigators will explore whether the detrimental impact of this lifestyle can be mitigated by daily tea consumption (equivalent to 6 cups/day). To explore this hypothesis, the investigators will perform measurements of these parameters before and after 7-days of reduced physical activity and overfeeding, with and without the combination of daily tea ingestion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 18-55 years
- •Habitually active (>8,000 steps/day)
排除标准
- •Medical history of cardiovascular/metabolic disease
- •Family history of cardiovascular disease (first degree relatives)
- •On medication known to influence the cardiovascular system
- •BMI of <18 or >30 kg/m2
- •Known food allergies or special dietary requirements
- •Vaccination (<1 week) due to induced systemic inflammatory reaction
研究组 & 干预措施
Placebo tea
Tea to be ingested 3 times per day for 7 days.
干预措施: Placebo tea (Dietary Supplement)
Active (green) tea
Tea to be ingested 3 times per day for 7 days.
干预措施: Green tea (Dietary Supplement)
结局指标
主要结局
Insulin sensitivity
时间窗: Post 7 day intervention
This will be measured following a carbohydrate-rich meal tolerance test (MTT) after an overnight fast, combined with regular venous blood sampling of insulin and glucose.
次要结局
- Vascular function(Post 7 day intervention)
研究者
Kirsty Woodward
PhD Student
Liverpool John Moores University