Efficacy of multimodal analgesia before and after impacted mandibular third molar surgery : A Prospective Multicenter Study
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 66
研究概览
简要总结
- In Group A, experimental drug significantly reduces pain at 3 and 6 hours after tooth extraction compared to taking a placebo, and also lowers the intensity of the initial perceived pain. - In Group B, experimental drug significantly reduces pain at 1 and 6 hours after tooth extraction compared to taking a placebo, and delays the onset of initial perceived pain. - There is no significant association between the use of experimental drugs and the need for additional analgesics within 12 hours post-surgery in both group A and B. - There is no significant association between the use of experimental drugs in both group A and B, and the occurrence of adverse reactions (drug-related side effects). - No other abnormal cases were observed in vital signs, physical examinations, or medical procedures.
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 19(Year) 至 40(Year)（—）
- 性别
- All
入选标准
- •Healthy adult males and females without systemic diseases aged 19 to 40 years old
- •-Those who have no abnormal findings on blood tests (CBC, aPTT, PT) conducted within the last 3 weeks
- •-When the impaction of both mandibular third molars is confirmed
- •-On panoramic radiographs, more than 1/3 of the crown is covered with the alveolar bone and need to be surgically extracted.
- •(including both gingival incision, tooth separation, bone removal)
- •-A person who fully understands and agrees with the purpose of the research and voluntarily permits participation in the research
排除标准
- •- Have a history of allergy on drugs used in this study
- •(Celecoxib, tramadol, acetaminophen, cefaclor, zaltoprofen, rebamipide)
- •-If there is pericoronitis or benign lesions on the impacted mandibular third molars
- •- If you need to take the analgesic drugs continuously until the time of extraction and maintains analgesic effect
- •-Pregnant or lactating person
- •-Smokers and others who are judged to be inappropriate to participate in clinical trials