Circadian Modulation of Grape Consumption and Oxidative Stress Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Urine F2-isoprostane
研究概览
简要总结
This study investigated the effects of time-of-day of grape consumption on high-fat meal-induced oxidative stress.
详细描述
Grape consumption acts on the immune system to produce antioxidant and anti-inflammatory effects. Since immune activity demonstrates circadian rhythmicity, with peak activity occurring during waking hours, the timing of grape intake may influence the magnitude of its antioxidant effect. This study followed a 2 x 2 factorial randomized, controlled design wherein healthy men and women (n = 32) consumed either a grape or placebo drink with a high-fat meal in the morning or evening. Urine was collected for measurements of biomarkers of oxidative stress and grape metabolites at baseline and post-meal at hour 1 and hours 1-6
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-50 y
排除标准
- •Employed in shift or night work
- •Extreme early or late chronotype
- •Presence of acute infection or chronic inflammatory disease
- •Heavy aerobic exerciser
- •Greater than moderate alcohol intake
- •Pregnancy or lactation
- •Use of non-steroidal anti-inflammatory medications or antioxidant dietary supplements.
结局指标
主要结局
Urine F2-isoprostane
时间窗: hours 1-6
Oxidative stress marker
次要结局
未报告次要终点
研究者
Cynthia Blanton
Professor
Idaho State University