NCT01236495已完成4 期
Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 Milligram for Post Lobectomy (Lung) Analgesia
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- pethidine requirement
研究概览
简要总结
The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.
详细描述
Thoracotomy causes severe pain to the patients. Continuous thoracic epidural is a gold standard for postoperative pain. However, it needs skill. There are many alternatives such as spinal morphine, intercostal nerve block, cryoalangesia or interpleural block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 year and < 70 year
- •Patient ASA physical status I-III.
- •Scheduled for thoracotomy with lobectomy.
- •Can operate a patient-controlled analgesia (PCA) device.
排除标准
- •Known hypersensitivity to morphine or pethidine
- •History of bleeding tendency.
- •Known case of infection at the back
- •Patient refuse for spinal anesthesia
- •History of cerebrovascular disease.
- •Scheduled for video-assisted thoracoscopic lobectomy.
- •Need mechanical ventilatory support during postoperative period
研究组 & 干预措施
spinal morphine 0.2 mg
Experimental
spinal morphine 0.2 mg
干预措施: spinal morphine 0.2 mg (Drug)
spinal morphine 0.3 mg
Active Comparator
spinal morphine 0.3 mg
干预措施: spinal morphine 0.3 mg (Drug)
结局指标
主要结局
pethidine requirement
时间窗: 48 hours
Total pethidine requirement during 48 hours postoperative
次要结局
未报告次要终点
研究者
Sirilak Suksompong
Associate Professor
Mahidol University
研究点 (1)
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