Biomarker Analysis in COVID and Post-COVID Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Biomarker analysis in CSF
研究概览
简要总结
Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system. We investigate cpost-COVID-19 patients with persistent headache lasting longer than 3 weeks, to hospitalized acute COVID-19 patients with neurological symptoms and to other non-COVID-19 disease-controls. Readout are neurologial and glial biomarkers in CSF.
详细描述
Measurements of neuronal and glial markers in CSF were performed on a SIMOA analyzer (Quanterix) using the Neurology 4-Plex A (Nf-L, Tau, GFAP, UCH-L1) kit.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of COVID, Parkinson's disease, primary headache, Multiples Sclerosis, facial paralysis
- •Persistent post-COVID-19 headache after 3 months of infection
- •Post COVID-patients without persistent headache
- •must be able to perform lumbar puncture
- •Exclusion criteria
- •unknown history of COVID infection
- •lumbar puncture not possible
排除标准
- 未提供
结局指标
主要结局
Biomarker analysis in CSF
时间窗: after 3 months of initial infection
Levels of Nf-L, Tau, GFAP, UCH-L1 in CSF
次要结局
未报告次要终点
研究者
Laura de Boni
Principal investigator
University Hospital, Bonn