LARGE SPONTANEOUS PORTOSYSTEMIC SHUNTS (SPSSs) IN PATIENTS WITH LIVER CIRRHOSIS. CLINICAL AND RADIOLOGICAL CHARACTERISTICS.
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Number of cirrhotic patients that develop hepatic encephalopathy as a decompensation
研究概览
简要总结
The purpose of this study is to perform a multicentre registry of cirrhotic patients who had been submitted to an imagining technique in recent years (angio-CT scan or abdominal MRI), in order to collect anatomical and clinical information. The main objective will be focused on the study of portosystemic shunts and their relation with portal hypertension.
Patient with liver cirrhosis submitted to an abdominal angio-CT scan or a MRI from year 2010 to 2014 will be included in the study. The chosen imaging technique will be angio-CT preferably, but MRI data will also be available. Patients will be identified in every hospital by means of the registry of coded diagnoses and the lists of complementary tests performed. Clinical and radiological data of every patient will be collected. The clinical variables will be obtained from reviewing the patient clinical history. The radiological parameters will be gathered by means of the systematic review of the angio-CT or MRI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Liver cirrhosis
- •An evaluable imaging test (angio-CT or MRI) performed by any reason in the study period (from January 2010 to December 2014)
排除标准
- •Presence of previous surgical shunts
- •Prior liver transplant
- •Neurological or psychiatric disorder that do not permit to establish the diagnosis of hepatic encephalopathy
- •Presence of hepatocellular carcinoma beyond Milan criteria
- •Terminal disease
结局指标
主要结局
Number of cirrhotic patients that develop hepatic encephalopathy as a decompensation
时间窗: 4 years
Number of cirrhotic patients with a portosystemic shunt detected by angio-CT scan or MRI
时间窗: 4 years
次要结局
- Number of cirrhotic patients that develop a decompensation (ascites, variceal bleeding, spontaneous bacterial peritonitis, hepatorenal syndrome)(4 years)
- Type of portosystemic shunts detected by angio-CT scan or MRI(4 years)