Effects of Vagus Nerve Transcutaneous Electric Stimulation on autonomic, hemodynamic and inflammatory markers in patients with Metabolic Syndrome

niversidade Nove de Julho-UNINOVE0 个研究点开始时间: 2020年1月7日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Elected individuals met all the criteria listed below:
•Diagnosis of Metabolic Syndrome based on newly established criteria - three abnormal findings out of five qualify a person for the diagnosis of Metabolic Syndrome:
•Waist circumferential increase ( equal to or greater than 102cm in men; equal to or greater than 88cm in women);
•Increased triglycerides (equal to or higher 150 mg/dL);
•Reduced HDL-C (equal to or less than 40mg/dL in men; equal to or less than 50mg/dL in women);
•Increased blood pressure (systolic equal to or higher 130mmHg); and/or diastolic equal to or higher 85mm Hg);
•High fasting blood glucose (equal to or higher 100mg / dL);
•Patient declaration of stable weight and diet for at least six months until study entry;
•Normal renal function;
•Normal thyroid function;
•Able to declare written consent and compliance with study taxation along the study.

•Subjects were not eligible to participate in the study if they met any of the exclusion criteria listed below:
•On antidiabetic medication or with HbA1c greater than 8.0%;
•Triglyceride levels equal or greater than 400mg / dL or on lipid-lowering medication;
•Serum alanine transaminase (AST) and / or aspartate transaminase (ALT) levels higher than 200U / L;
•Resting systolic pressure greater than or equal to 160 mm Hg; resting diastolic pressure greater than or equal to 100 mm Hg;
•Using antihypertensive drugs that interfere (beta blockers) with HRV;
•History of debilitating chronic diseases;
•Volunteers presenting any active neoplasm; cutaneous lesion and / or sensitivity deficit of the left auricle; being on radiotherapy and / or chemotherapy and immunosuppressive treatment, patients with chronic infectious diseases (including hepatitis, Acquired Immunodeficiency Syndrome).

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