The Effect of Maternal Long Term High Flow Oxygen Administration During Labor on Umbilical Cord Blood Gases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 140
- 试验地点
- 3
- 主要终点
- Cord arterial partial pressure of oxygen
研究概览
简要总结
Supplementary oxygen is routinely administered to patients, even those with adequate oxygen saturations, in the belief that it increases oxygen delivery. However, oxygen delivery depends not just on arterial oxygen content but also on perfusion.
Maternal oxygen administration has been used in an attempt to lessen fetal distress by increasing the available oxygen from the mother. However, the effect of supplemental maternal oxygen therapy on fetal acid base status has been debated for more than seven decades.
The investigators found the use of 2 L/min maternal oxygen during the second stage of labor did not adversely affect either the umbilical artery pH value or the fetal heart rate (FHR) pattern distribution.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •at term (>37 weeks, <42 weeks), singleton, cephalic presentation, spontaneous or induced labor, normal labor, category I FHR tracings, 2 to 3 cm of cervical dilation in nulliparity, 1 to 2 cm of cervical dilation in multipara, informed consent.
排除标准
- •respiratory or cardiovascular disease, diabetes mellitus or insulin-treated gestational diabetes mellitus, hypertension or preeclampsia, oligohydramnios, fetal growth restriction, placental abruption, cephalopelvic disproportion, meconium-stained amniotic fluid, tachysystole, having received O2, uterine incision (myomectomy or perforation), anemia, fever, chorioamnionitis, tobacco or alcohol use, disorders in oxygen saturations, hypotension, uncomfortable with facemask.
结局指标
主要结局
Cord arterial partial pressure of oxygen
时间窗: within 30 to 60 seconds of birth
Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord arterial pH values
时间窗: within 30 to 60 seconds of birth
Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord venous partial pressure of carbon dioxide
时间窗: within 30 to 60 seconds of birth
Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord venous pH values
时间窗: within 30 to 60 seconds of birth
Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord arterial partial pressure of carbon dioxide
时间窗: within 30 to 60 seconds of birth
Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord venous partial pressure of oxygen
时间窗: within 30 to 60 seconds of birth
Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
次要结局
- Rate of abnormal fetal heart tracing(at 1 minute after birth)
研究者
Yunhai Chuai
Clinical Professor of Obstetrics and Gynecology, Principal Investigator
Navy General Hospital, Beijing