Helicobacter Pylori Resistance. A Study of Morbidity, Immunological and Clinical Phenotypes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 185
- 主要终点
- Characterization of patients with chronic HP infection resistant to previous conventional triple therapy
研究概览
简要总结
The main goal of the study was to characterize the morbidity, immunological, microbiolical and clinical phenotypes of patients with treated- resistance to Helicobacter pylori (HP) infection, and the effect of triple therapy including the levofloxacin. Control groups were newly diagnosed, previously infected and never infected HP patients
详细描述
See Nestegard O, et al. PLOS ONE | https://doi.org/10.1371/journal.pone.0238944 September 23, 2020
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients referred to a GI- unite with upper GI complains and performing an upper endoscopy -
排除标准
- •Patients with severe chronic diseases and not willing to participate
研究组 & 干预措施
Helicobacter pylori resistance
Patients with treatment resistance to Helicobacter pylori treatment registered at GI-unites from 1990-2012 and included from 2010 to 2012. These patients were treated with a triple therapy of levofloxacin, amoxicillin and proton inhibitor for 10 days
干预措施: levofloxacin, amoxicillin, clarithromycin (Drug)
Newly diagnosed Helicobacter pylori
Patients with newly diagnosed Helicobacter pylori infection from 2010-2012.These patients were treated with a triple therapy of clarithromycin, amoxicillin and proton inhibitor for 10 days
干预措施: levofloxacin, amoxicillin, clarithromycin (Drug)
结局指标
主要结局
Characterization of patients with chronic HP infection resistant to previous conventional triple therapy
时间窗: 2010-2012
Clinical data including endoscopy, histology, microbiological data including resistance measurements, immunological data (mucosal tranacrips), effect of triple therapy
Endoscopy
时间窗: 2010-2012
endoscopic description of mucosa bye endoscopy
Histology
时间窗: 2010-2012
Histological characterizations of inflammation (Sydney) of gastric mucosa
Immunology
时间窗: 2010-2012
Immunological mucosal characterizations of pro- and antiinflammatory cytokine transcript (PCR)
HP microbiology
时间窗: 2010-2012
HP microbiology sensitivity to metronidazol, amoxicillin, clarithromycine, levofloxacin and tetracycline
次要结局
未报告次要终点
研究者
Jon Florholmen
professor, MD
University Hospital of North Norway