NCT00636766已完成不适用
Atherosclerotic Plaque Texture-Experimental and Clinical Study on the Diagnostic and Therapeutic Strategies of Atherosclerotic Plaque Vulnerability
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Ultrasound and immunohistochemical parameters of plaque stability; novel cardiovascular risk factors
研究概览
简要总结
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor antagonists on atherosclerotic plaque texture in patients with cardiovascular risk and animals prone to atherosclerosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Carotid atherosclerosis
- •Femoral atherosclerosis
- •Cardiovascular risk
排除标准
- •Heart failure
- •Renal disease
- •Liver disease
- •Life-threatening diseases
研究组 & 干预措施
1
Experimental
干预措施: atorvastatin (Drug)
1
Experimental
干预措施: rimonabant (Drug)
1
Experimental
干预措施: rosiglitazone (Drug)
1
Experimental
干预措施: metformin (Drug)
结局指标
主要结局
Ultrasound and immunohistochemical parameters of plaque stability; novel cardiovascular risk factors
时间窗: 3 years
次要结局
- Long-term cardiovascular outcomes(3 years)
研究者
Nikolaos Kadoglou
MD,PhD
Aristotle University Of Thessaloniki
研究点 (1)
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