The Influence of Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation on Muscle Fatigue
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Time to Task Failure
研究概览
简要总结
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) can impact muscle fatigue. The main questions it aims to answer are:
- Does tDCS of the left DLPFC increase the time that a fatiguing contraction can be maintained?
- Does tDCS of the left DLPFC decrease the rate of increase of muscle activity, force error, and standard deviation of force during a fatiguing contraction.
Researchers will compare tDCS of the left DLPFC to a SHAM stimulation (a type of stimulation that feels like real tDCS but does not elicit physiological effects) to see if tDCS of the left DLPFC works to reduce the progression of muscle fatigue.
Participants will:
Performing two experimental sessions held 3-10 days apart (usually 7 days) Perform a 9 hole pegboard test, maximum voluntary contractions, and a fatiguing contraction.
详细描述
Transcranial direct current stimulation (tDCS) delivered to the dorsolateral prefrontal cortex (DLPFC) can increase endurance time in lower body tasks. Therefore, the purpose of this study is to examine the effect of DLPFC-tDCS on the time to task failure (TTF) of a fatiguing contraction performed by hand muscles. The study will use a double-blind, randomized, SHAM-controlled, crossover design with each participant performing two experimental sessions held 3-7 days apart. The only difference between the two sessions will be the type of stimulation (tDCS or SHAM; counterbalanced) applied concurrent with the fatiguing contraction. The fatiguing contraction will involve gripping a manipulandum with the index finger and thumb. This will be accomplished by using a precision grip and matching an isometric target equal to 15% of the maximum voluntary contraction (MVC) for as long as possible until task failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Double-blind
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to provide informed consent
- •Free from any neurological or psychiatric condition
- •Age between 18-50 years old
- •Right-handed (as determined by the Edinburgh Handedness Inventory)
排除标准
- •An uncontrolled medical condition (i.e. hypertension, diabetes, etc)
- •Metal in the skull or the eye, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, and metal fragments in the eye.
- •Hearing loss diagnosed by a doctor and requiring a hearing aid. Have had a brain tumor, a stroke, head trauma, epilepsy or a history of seizures, have a neurological disorder, a movement disorder, or have a head injury that involved being passed out for more than a few seconds.
- •History of migraines
- •implanted defibrillator or implanted neurostimulator
- •pregnant or thought to be pregnant. This must be an exclusion criterion as there are few medical papers available regarding the effects of tDCS on the unborn child/fetus or expectant mother. Thus, if you are pregnant or thought to be pregnant you cannot participate in the study. If you find out you are pregnant in the week timeframe between experiment 1 and experiment 2, you should withdraw from the study as we cannot perform the second experiment in that case.
- •Not done a similar fatigue study in the laboratory in the last 7 days.
结局指标
主要结局
Time to Task Failure
时间窗: 5 months
The time in seconds that a fatiguing contraction can be held
Fatigue Index
时间窗: 5 months
The percent decline in force between the maximum voluntary contractions performed before and after the fatiguing contraction
次要结局
- Force error(5 months)
- Standard deviation of force(5 months)
- Average EMG activity(5 months)
- 9 Hole Pegboard Test(5 months)
研究者
Brach Poston
Associate Professor
University of Nevada, Las Vegas