The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial

简要总结

主要结局

次要结局

• Days of therapy for specific sub-groups of patients, including patients whose physicians elected to opt-out of the intervention(30 days post-randomization)
• Negative outcomes as measured by individual clinical outcome components in the DOOR(30 days post-randomization)
• Negative outcomes as measured by number of days patient has a central line(30 days post-randomization)
• percent of eligible patients with antibiotic de-escalation(5 days from initial date of suspected sepsis)
• Negative outcomes as measured by re-initiation of antibiotic therapy after greater than 48 hours with no antibiotics(30 days post-randomization)
• prescriber type(within 3 days (96 hours) of initial date of suspected sepsis)
• prescribers' reported rationale for opting out(within 3 days (96 hours) of initial date of suspected sepsis)
• Distributions of DOOR(up to 2 years)
• number of eligible patients in whom the prescriber chose to opt-out(within 3 days (96 hours) of initial date of suspected sepsis)
• Percent of subjects who received an infectious disease consultation after implementation of the Opt-Out Protocol(30 days post-randomization)
• Negative outcomes as measured by length of hospital stay(30 days post-randomization)
• Number of patients in whom the safety screen was applied(within 3 days (96 hours) of initial date of suspected sepsis)
• Number of patients the safety screen excluded from the opt-out procedure(within 3 days (96 hours) of initial date of suspected sepsis)
• number of eligible patients in whom the opt-out procedure was applied(within 3 days (96 hours) of initial date of suspected sepsis)