Hormones and Muscle– Unravelling the metabolic pathways of endocrine myopathiesA translational magnetic resonance spectroscopy and imaging pilot study - Hormones and Muscle

Medical Univerity of Vienna0 个研究点目标入组 83 人开始时间: 2022年1月13日最近更新: 2022年3月14日

适应症

试验速览

暂无简介。

•Inclusion criteria (subclinical hypothyroidism):
•(i) TSH > 4µU/ml, fT4 within the reverence range.
•(ii) Age between 18 and 70 years
•(i) Age between 18 and 70 years
•(ii) Diagnostic criteria fulfilling primary hyperparathyroidism (calcium > 2,5 mmol/l;
•PTH > upper limit of normal; fractional 24h urinary calcium excretion > 1 %) or hypoparathyroidism (calcium < 2,15 mmol/l; PTH < lower limit of normal)
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 83
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•(i) any known disorder of thyroid function, including subclinical and overt hypo- or hyperthyroidism,
•(ii) positive thyroid autoantibodies (i.e. TRAK, TG-AK, TPO-AK),
•(iii) current or previous medication for thyroid disorders,
•(iv) severe metabolic or liver illness (HbA1c > 8%, Triglycerides > 500 mg/dl,
•Cholesterol > 300 mg/dl, AST & ALT > 3 x upper limit of normal range)
•(v) pregnancy
•(vi) breast feeding
•(vii) general MR-contraindications, including metal devices or other magnetic material
•hazardous for MR investigation and claustrophobia
•(viii) statin therapy

发起方

Medical Univerity of Vienna