The effect of using oxytocin in individuals with body dysmorphic disorder (BDD)

Swinburne University of Technology0 个研究点目标入组 46 人开始时间: 2022年3月16日最近更新: 2022年3月21日

适应症

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•Participants will i) be aged between 18-55 years (inclusive); ii) have a primary diagnosis of BDD according to the Diagnostic and Statistical Manual-5 (DSM-5); iii) score of 24 or higher on the BDD-YBOCS (to ensure at least moderate symptom severity); iv) have an estimated IQ of 70 or higher as assessed using the Test of Premorbid Functioning (TOPF) to ensure no intellectual disability and study instructions are understood; v) have been stabilised on psychotropic medications, if prescribed, for 8weeks or longer; vi) be right-handed (to meet eligibility for MRI); vii) utilising effective contraception if female and of childbearing age; and viii) have capacity to consent to the study. Further, BDD patients frequently report co-morbid depression, social anxiety and psychoses. To ensure our sample is representative, patients with co-morbidities will be included.

•Participants will be excluded if i) substance use disorder is present; ii) they are unable to meaningfully converse in, or read, English; iii) they have metal implants or a history of claustrophobia (to meet eligibility for an MRI); iv) neuroendocrine dysfunction or steroid use is present; vi) they have been diagnosed with any known neurological disorder; v) they are currently pregnant or breastfeeding, vi) have an ongoing sinus condition and vii) history of hypersensitivity to oxytocin.

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