Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Total morphine consumption
研究概览
简要总结
This study aims to compare the costotransverse foramen block (CTFB) with thoracic paravertebral block (TPVB) in patients undergoing thoracotomy for lung cancer.
详细描述
Thoracotomy is known to be one of the most painful surgeries. Managing post-thoracotomy pain is a major clinical challenge, as about 75% of patients report moderate to severe pain afterward.
Various regional and central analgesia techniques, such as thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), and erector spinae plane block (ESPB), are employed in a multimodal approach. Although TEA has traditionally been considered the gold standard for thoracotomy pain control, concerns about its side effects have prompted the exploration of alternatives.
The costotransverse foramen block (CTFB), a recently introduced technique, has been examined in both cadaveric and case studies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years and ≤ 65 years old.
- •American Society of Anesthesiologists (ASA) physical status II-III.
- •Body mass index 18-35 kg/m
- •Patients scheduled for thoracotomies for lung cancer.
排除标准
- •Patient refusal.
- •History of sensitivity to local anesthetics.
- •History of psychological disorders.
- •Contraindication to regional anesthesia, e.g., local sepsis, pre-existing peripheral neuropathies, and coagulopathy.
- •Severe respiratory, cardiac, hepatic, or renal disease.
- •Morbid obesity.
- •Uncooperative patients.
- •Patients on chronic pain therapy.
研究组 & 干预措施
CTFB Group
Patients will receive an ipsilateral ultrasound-guided costotransverse foramen block with injection of 20 ml bupivacaine 0.25%.
干预措施: Costotransverse foramen block (Other)
TPVB Group
Patients will receive an ipsilateral ultrasound-guided thoracic paravertebral plane block with injection of 20 ml bupivacaine 0.25%.
干预措施: Thoracic paravertebral plane block (Other)
结局指标
主要结局
Total morphine consumption
时间窗: 24 hours postoperatively
If the visual analog scale (VAS) is ≥ 4, rescue analgesics will be administered in the form of a 4 mg bolus of morphine.
次要结局
- Duration of analgesia(24 hours postoperatively)
- Degree of pain(48 hours postoperatively)
- Intraoperative fentanyl consumption(Intraoperatively)
- Mean arterial blood pressure(4 hours postoperatively)
- Heart rate(4 hours postoperatively)
- Incidence of block-related side effects(4 hours postoperatively)
- Incidence of side effects(4 hours postoperatively)
研究者
Mai Mohamed El Rawas
Assistant professor of Anaesthesia, Intensive Care and Pain Management, National Cancer Institute, Cairo University Cairo University, Cairo, Egypt.
National Cancer Institute, Egypt