Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Upper airway elasticity
研究概览
简要总结
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The investigators will assess the viscoelastic properties of the pharyngeal airway and its role in PEN.
详细描述
In obstructive sleep apnea, the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea.
The investigators will test how the viscoelastic properties of the airway influence PEN. To this end, the investigators will visualize the pharynx of sleep apnea patients using a thin endoscope and will induce central apneas during sleep. Pharyngeal cross-sectional area will be recorded during incremental changes in pharyngeal pressure during central apneas.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Normal subjects or patients with OSA
排除标准
- •Any unstable cardiac condition (other than well controlled hypertension) or pulmonary problems.
- •Any medication known to influence breathing, sleep/arousal or muscle physiology
- •Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia)
- •Claustrophobia
- •Inability to sleep supine
- •Allergy to lidocaine or oxymetazoline hydrochloride
- •For women: Pregnancy
研究组 & 干预措施
Viscoelastic properties of the airway
干预措施: Induced central apneas (Other)
结局指标
主要结局
Upper airway elasticity
时间窗: 10 - 40 seconds
The investigators will determine elasticity of the upper airway during induced central apneas by dividing the change in airway pressure by the change in airway cross-sectional area. The time frame for the outcome of this study is equal to the duration of the induced central sleep apnea (usually less than 40 seconds).
次要结局
未报告次要终点
研究者
David Andrew Wellman
Principal Investigator
Brigham and Women's Hospital