The effect of exercise-induced hyperlacticacidemia on counterregulatory responses, symptoms, cognitive function and brain lactate accumulation during hypoglycemia in patients with type 1 diabetes with and without hypoglycemia unawareness and normal controls - Effect of endogenous lactate on defenses against hypoglycemia

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•age: 18-40 years
•BMI: 18-30 kg/m2
•blood pressure <160/90 mmHg
•Recreationally active: i.e. taking part in competitive sport or regular exercise/physical activity, of a non-professional nature, once or more a week;For T1DM subjects:
•Diabetes duration >1year
•HbA1c: 42-75 mmol/mol (6-9%)
•Outcome clarke questionnaire: 0-1 (normal awareness) or >=3 (hypoglycemia unawareness)

•- Inability to provide informed consent
•- Presence of any medical condition that might interfere with the study protocol, such as brain injuries, epilepsy, a major cardiovascular disease event or anxiety disorders
•- Use of any medication, except for oral contraceptives
•- For the MR study: MR(I) contraindications (pregnancy, severe claustrophobia, metal parts in body)
•- Orthopedic and/or neurological diseases that impair exercise
•- Cardiopulmonary disease ;For T1DM subjects:
•- complications of T1DM, e.g. proliferative retinopathy, neuropathy or overt/clinical albuminuria
•- Use of any other medication than insulin, except for oral contraceptives or stable thyroxine supplementation therapy

发起方

niversitair Medisch Centrum Sint Radboud