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临床试验/CTRI/2026/02/103060
CTRI/2026/02/103060尚未招募不适用

Comparative clinical trial to evaluate the efficacy of Patradi Kwatha with Madhu as an add on therapy for Atorvastatin and Tab. Atorvastatin alone in the management of Dyslipidemia w.s.r. to Medoroga

Amol Chandrakant Gulve1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2026年2月18日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
90
试验地点
1

研究概览

简要总结

In the conventional part usually the treatment is started by administering drug with Hypolipidemic agents includes bile acid sequestrates, Niacin, Fibric acid and HMG-COA reductase inhibiters. Standard treatment with statins groups (Atorvastatin) help to normalized the biochemical markers only i.e. Lipoproteins. But it has very low effect on the symptoms like snigdha-angata, shramahani, daurbalyata. Due to such unsatisfactory results on the symptomatic relief it has prompted the question of whether the Atorvastatin treatment is sufficient for all Patients or whether alternative therapies could be adopted. Being a part of Ayurveda medicine system it is necessary to search out the effective and safe medicinal therapy which can be used as an add on therapy for Atorvastatin to help the patients to get symptomatic relief.

Dyslipidemia/ Medorog is Kapha dushti pradhan and santarpanjanya vyadhi. All these drugs in patradi kwatha may help to normalize the vitiated Kapha –Vaat Dosha with their Ushna virya and Katu Vipak. With the help of ruksha, laghu, vishad, lekhanam guna of Madhu it balances Kapha and pitta dosha. Antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardiovascular-disease lowering activity of Haridra and tejapatra has studied in clinical trials. When this Patradi Kwatha along with Madhu will be used as add on therapy for Atorvastatin, it will be beneficial for reduction in symptoms, may help to minimize side effects of Atorvastatin with its dose and duration reduction. It may provide the good adjuvant treatment option for the unsatisfactory treatment with liposuction alone in dyslipidemia. So the Patradi Kwatha along with Madhu is selected for present study

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
20.00 Day(s) 至 60.00 Day(s)(—)
性别
All

入选标准

  • Within one year of recently diagnosed patients of Medoroga (Dyslipidemia) on the basis of Lipid Profiles.
  • Patients having Serum Cholesterol level 240mg/dl to 350mg/dl.
  • Cholesterol = 200 to 239 mg/dl.) 3) Serum Triglyceride levels 150mg/dl to 250mg/dl ( Sr.Triglyceride = less than 150 mg/dl) 4) LDL level 100mg/dl to 150mg/dl (normal range= less than 100mg/dl) 5) HDL 20mg/dl to 30mg/dl (normal value above 40mg/dl) 6) Adult age between 20-60 years.
  • Patients having clinical symptoms of Medodushti among followingKshudra Shwasa (Breathlessness on exertion) Sarvakarmasu Ashaktata (difficulty in normal daily activity) Swedadhikya (Excessive sweating) Daurbalya (Weakness).

排除标准

  • Thyroid Disorder, genetic disorders, autoimmune disorders.
  • Patients suffering from chronic Anaemia, Renal insufficiency.
  • Co morbid patients like HTN, DM, Insulin dependent Diabetes mellitus, IHD, Angina Pectoris, MI.
  • Patients receiving Anti retro Viral Therapy.
  • Pregnancy and Lactation.
  • Age less than 20 years and more than 60 years.

研究者

发起方
Amol Chandrakant Gulve
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Amol Chandrakant Gulve

Shree Saptashrungi Ayurved College and Hospital

研究点 (1)

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