Electrohaemodynamic Activity in Epileptic Children: Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- multimodal high-resolution EEG-NIRS
研究概览
简要总结
Evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis to spatial localization of epileptogenic foci
详细描述
This study is designed to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children between the ages of 6 and 18 years
- •with drug-refractory partial epilepsy, presenting interictal spikes on standard EEG recordings.
排除标准
- •Children with a serious congenital malformation.
- •Refusal from one of the parents or the child.
- •Children with generalized epilepsy or diffuse interictal spikes.
- •Children with severely impaired general status and vital functions.
- •Children with dermatosis of the face or scalp.
- •Children under the age of 6 years or adults over the age of 18 years.
结局指标
主要结局
multimodal high-resolution EEG-NIRS
时间窗: Day 0
to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.
次要结局
- Functional MRI(Day 0)