euro-cognitive effects of tyrosine supplementation in older adults - Tyrosine and the aging brain

Radboud Universiteit Nijmegen0 个研究点目标入组 28 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•Inclusion criteria (zie sectie 4.2 op pagina 12 van het protocol)
•In order to be eligible to participate in this study, subjects must meet all of these criteria:
•- Age: 60-75 years old
•- Proficient knowledge of the Dutch language
•- Right-handed
•- Willing to perform tasks in the MRI scanner, to come to the centre on three occasions, consuming tyrosine or a placebo and willing to fast the night before the two test sessions.

•Exclusion criteria (see section 4.3 on page 12 of the protocol)
•A potential subject who meets any of the following criteria will be excluded from participation in this study (for a checklist see F1 Intake Questionnaires and Checklists):
•- Mini Mental State Examination score < 24
•- HADS score > 11
•- Estimated IQ < 85 (based on Nederlandse Leestest voor Volwassenen (NLV) -score)
•- (History of) clinically significant psychiatric disorder
•- (History of) clinically significant neurological disorder, such as brain infarct, Parkinson*s Disease, chronic migraine, Diabetes Mellitus
•- First degree family history of schizophrenia, bipolar disorder or major depressive disorder
•- Thyroid problems and low-protein diet
•- Daily use of beta blockers
•- Using medication that can interfere with tyrosine*s action; monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids
•- General medical conditions, such as repetitive strain injury (RSI) or sensori-motor handicaps, blindness or colorblindness, as judged by the investigator
•- (History of) abuse of drugs or alcohol
•- Habitual smoking, i.e. more than a pack of cigarettes per week
•- Participation, current or within the past twelve months, in a specific cognitive training study
•- Contra-indications for MRI:
•o Metal objects or fragments in the body that cannot be taken out
•o Active implants in the body
•o Using medical plasters
•o Previous head surgery
•o Claustrophobia

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