跳至主要内容
临床试验/NCT02788799
NCT02788799Unknown不适用

Clinical Impact of Pre-hospital Posterior ECG Leads Implementation for Identifying Occlusion of Left Circumflex Coronary Artery in ST Segment Elevation Myocardial Infarction

Rigshospitalet, Denmark1 个研究点 分布在 1 个国家目标入组 1,200 人开始时间: 2017年2月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
1,200
试验地点
1
主要终点
Proportion of patients with LCX occlusion as culprit artery in the intervention group compared to the control group

研究概览

简要总结

Along with symptoms of chest pain, the presence of ST segment elevations on ECG is the criterion usually used in practice to identify patients with acute coronary artery occlusion and is essential for the direct and acute referral of patients for primary PCI. However, ECG does not always reflect changes in the posterior wall of the heart, often equivalent to the left circumflex coronary artery's (LCX) supply area, resulting in an underrepresentation of LCX as culprit artery in STEMI populations. There is a general concern that some patients with genuine acute occlusion of LCX may present without ST segment elevation and be denied reperfusion therapy, resulting in larger infarction and worse outcome.

The aim of this trial is to implement record of posterior ECG leads (V7, V8 and V9) in addition to the standard 12-lead ECG in the pre-hospital setting and to evaluate the clinical impact of this implementation: In comparison to a control cohort of STEMI patients diagnosed with a pre-hospital standard 12-lead ECG prior study start, the investigators hypothesize that introducing V7-V9 leads as a clinical routine in the pre-hospital setting will identify patients with STEMI involving LCX and with a non-diagnostic standard 12-lead ECG.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Other

入排标准

性别
All
接受健康志愿者

入选标准

  • Intervention group:
  • All STEMI patients referred directly from the pre-hospital setting, treated with primary PCI and with available standard 12-lead ECG and ECG with V7-V9 leads.

排除标准

  • STEMI patients treated with primary PCI and no ECG with V7-V9 leads.

结局指标

主要结局

Proportion of patients with LCX occlusion as culprit artery in the intervention group compared to the control group

时间窗: Day one - culprit lesion treated with primary PCI

次要结局

  • Proportion of patients in the intervention group with STEMI involving LCX artery, non-diagnostic standard 12-lead ECG and ST segment elevation >0,5 mm in ≥2 leads in posterior ECG leads (V7-V9).(Day one - culprit lesion treated with primary PCI)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Yama Fakhri

MD

Rigshospitalet, Denmark

研究点 (1)

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