A cross-sectional study to assess night-shift work related exposures and their association with markers of biological perturbation - CLOCKWORK

niversiteit Utrecht0 个研究点目标入组 300 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•- Subject is between 18 years and 65 years of age by the time of performing the screening questionnaire.
•- Subjects are female.
•- Subjects are nurse or employed in a paramedic profession.
•- Subjects either have not worked in a profession requiring shift work for over 5 years, just started working in night shifts (<2 year) or worked in night-shifts for over 5 years.
•- Subjects are willing to give blood, fill out the questionnaires, and wear the sensors.;For the sub-study the same inclusion criteria apply with the exception of the last one. This criterion is replaced with:
•- Subjects are willing to give blood and fill out the questionnaires.

•- Subject is a smoker or ex-smoker for less than 6 months since baseline of study inclusion. Occasional smokers that have smoked less than 100 cigarettes in their lifetime are considered non-smokers.
•- Subject has a doctor diagnosed chronic disease/disorder (i.e. CVD, metabolic syndrome, diabetes).
•- Subject has/had cancer excluding non-melanoma skin cancer.
•- Subject uses beta-blockers, or melatonin supplementation.
•- Subject was pregnant in the last 6 months or is planning to become pregnant in the next 12 months.
•- Subject is in fertility treatment.;Exclusion criteria for the sub-study are the same

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