Registry and Biobank for Patients With Hypoparathyroidism Wuerzburg
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Subjective health status
研究概览
简要总结
Long-term conventional treatment of chronic hypoparathyroidism does not fully restore calcium homeostasis leading to increased morbidity, emergency events and reduced subjective health status. To further investigate general morbidity, hypocalcemic events, subjective and daily life performance in patients with chronic hypoparathyroidism a standardized interview as well as blood sampling and examinations such as echocardiography and renal ultrasound are performed.
详细描述
Design:
In a longitudinal prospective trial the comorbidities, mortality, hypocalcemic and hypercalcemic events and quality of life in patients with chronic hypoparathyroidism will be evaluated by a standardized interview, blood sampling and further examinations such as echocardiography and renal ultrasound.
Patients:
Patients will be recruited out of the patient population of the University Hospital Wuerzburg.
Statistical Analysis:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age of 18
- •chronic hypoparathyroidism (>12 months) under established therapy or chronic pseudohypoparathyroidism (>12 months) under established therapy
- •written informed consent
排除标准
- •age <18 years
- •no detailed documentation of hypo- or pseudohypoparathyroidism
结局指标
主要结局
Subjective health status
时间窗: 15 years
Assessment of the subjective health status by standardized quality of life (QoL) questionnaires (e.g. short form-36, Patient Health Questionnaire 28)
Comorbidites
时间窗: 15 years
Comorbidities such as renal diseases, cardiovascular disease, psychiatric diseases under treatment
次要结局
- Hypocalcemic and hypercalcemic events(15 years)
- Mortality(15 years)
研究者
Stefanie Hahner
Prof. Dr.
University of Wuerzburg