Effects of BFR Interventions on Muscle Function and Adaptations in Healthy Individuals and Individuals With COPD
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Muscle strength
研究概览
简要总结
The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for participants with COPD group are:
- •Diagnosis with COPD
排除标准
- •participants in the COPD group are
- •Having experienced an acute exacerbation of COPD within the last 6 weeks (Study A)
- •Taking part in pulmonary rehabilitation within the last 3 months (Study A)
- •Presenting with a history of thromboembolic event in the lower limbs.
- •Inclusion criteria for healthy participants are:
- •Age between 18 and 40 years.
- •Maximal oxygen uptake (VO2max) of >55 ml O2/kg/min for men and >50 ml O2/kg/min for women
- •BMI of <26 and normal ECG and blood pressure.
- •Exclusion criteria for healthy participants are:
- •chronic disease,
- •Use of prescription medication
- •Pain due to current or previous musculoskeletal injury
- •Resistance training more than once per week in the 12 months leading up to the intervention.
研究组 & 干预措施
BFR-ST and BFR-HIT
Participants will be allocated to a BFR intervention including resistance training and high-intensity intervals performed on a bicycle ergometer, both performed with BFR.
干预措施: BFR during training (Other)
HL-ST and HIT
Participants will be allocated to heavy load resistance training and high-intensity intervals performed on a bicycle ergometer, both performed without BFR
干预措施: BFR during training (Other)
BFR-P
Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR.
干预措施: BFR during rest (Other)
BFR-NMES
Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR with neuromuscular electrical stimulation (BFR-NMES) twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR-NMES.
干预措施: BFR during rest (Other)
Control group
Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will allocated to usual care, consisting of daily physiotherapy sessions.
干预措施: BFR during rest (Other)
结局指标
主要结局
Muscle strength
时间窗: Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)
Maximal voluntary isometric contraction of m. quadriceps femoris
次要结局
- Maximal oxygen consumption(Change assessed from before to after the 6 week intervention)
- Skeletal muscle mitochondrial respiration(Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B))
- Fiber cross-sectional area(Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B))
- Functional exercise capacity(Change assessed from before to after the 6 week intervention (only in individuals with COPD))
- Satellite cells(Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B))
- Lean mass(Change assessed from before to after the 6 week intervention)
- Myonuclei(Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B))
研究者
Morten Hostrup, PhD
Associate Professor
University of Copenhagen