NCT00197886已完成不适用
Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- L-lactate concentration in the rectum and stomach.
研究概览
简要总结
Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid.
This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Septic shock
- •NE-dose > 0.1 microg/kg/min
- •CI > 3.0 l/min/m2
排除标准
- •Age < 18, unable to obtain informed consent from relatives
- •Untreated hypertension
- •Pregnancy
- •Pathology in the rectum or stomach
- •Limitation of therapy
结局指标
主要结局
L-lactate concentration in the rectum and stomach.
次要结局
未报告次要终点
研究者
研究点 (2)
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