NCT04258826已完成1 期
A Single-Dose Study Using Functional Magnetic Resonance Imaging to Evaluate the Effect of LY3154207 in Healthy Subjects
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Change from Baseline in Intrinsic Functional Connectivity Among Resting-State Networks of the Brain
研究概览
简要总结
The purpose of this study is to learn more about how LY3154207 affects the brain of healthy participants by using magnetic resonance imaging. The study will last up to about nine weeks for each participant and may include up to four visits to the study center.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overtly healthy males and non-childbearing females, as determined through medical history and physical examination
排除标准
- •Have known or ongoing psychiatric disorders
- •Have contraindications to magnetic resonance imaging (MRI)
研究组 & 干预措施
LY3154207
Experimental
LY3154207 administered orally in one of two study periods.
干预措施: LY3154207 (Drug)
Placebo
Placebo Comparator
Placebo administered orally in one of two study periods.
干预措施: Placebo (Drug)
结局指标
主要结局
Change from Baseline in Intrinsic Functional Connectivity Among Resting-State Networks of the Brain
时间窗: Day 1, Approximately Day 28
Mean Connectivity and Mean Component Weight Between LY3154207 and Placebo in the Dorsal Attention Network (DAN), Frontoparietal Network (FPN), and Executive Control Network (ECN).
次要结局
未报告次要终点
研究者
研究点 (1)
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