NCT00168467已完成4 期
The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease
Baker Heart Research Institute2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2005年9月15日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Time to onset of claudication
研究概览
简要总结
One important clinical challenge in older individuals is maintaining mobility in the absence of pain. Peripheral arterial disease affects up to 12% of adults over 50 and impairs quality of life due to intermittent claudication causing pain and limiting mobility.
Conventional therapies have only modest effect in improving symptoms. The investigators hypothesise that angiotensin converting enzyme inhibition (with ramipril), which causes arterial vasodilation, also improves clinical symptoms in patients with peripheral arterial disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- — 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ankle-brachial index of <0.9 at rest in at least one leg
- •History of intermittent claudication (unilateral or bilateral) which was stable for 6 months
- •Evidence of superficial femoral artery stenosis or occlusion on duplex scan
- •Blood pressure <=160/90 mmHg
- •Stable medication regimen for at least 6 months and not previously treated with ACE inhibitors
排除标准
- •Limiting coronary artery disease
- •Renal Failure
- •History of hypertension
- •History of type 2 diabetes mellitus
结局指标
主要结局
Time to onset of claudication
Total exercise time during a standard treadmill test
Walking ability measured using the standard Walking Impairment Questionnaire
次要结局
- Leg Blood Flow using Duplex Ultrasound
研究者
研究点 (2)
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