Norepinephrine Titration In Patients With Sepsis Induced Encephalopathy: Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 2
- 主要终点
- Intensive care unit (ICU) mortality
研究概览
简要总结
The aim of our study is to compare between transcranial doppler pulsatility index and mean arterial blood pressure in guiding management of sepsis induced encephalopathy.
详细描述
Sepsis induced encephalopathy is the most frequent sepsis related organ dysfunction. It appears early during the course of infection, often before any other organ involvement in up to 70% of hospitalized septic patients and is associated with significant change of cerebral circulation caused by redistribution of blood flow during sepsis that accompanies the abnormal inflammatory response during an infection, in absence of direct central nervous system involvement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 years or older
- •Must had clinical diagnosis of sepsis induced encephalopathy.
排除标准
- •Refusal to participate in the study.
- •Cerebral infection.
- •Known cerebral lesions (Neoplasm, Traumatic brain injury, Stroke, Ischemic or hemorrhagic cerebrovascular lesions, high intracranial pressure).
- •Known severe carotid stenosis (>70％).
- •Intoxication due to drugs.
- •Pregnancy.
- •Patients supported by intra-aortic balloon pumb (IABP).
结局指标
主要结局
Intensive care unit (ICU) mortality
时间窗: 28 day or till death which earlier
Incidence of Intensive care unit (ICU) stay will be recorded
次要结局
- Outcome of encephalopathy(28 day)
- Cerebral perfusion pressure(24 hours)
- Length of ICU stay(At least 28 days)
- Mean arterial pressure(24 hours)
- Norepinephrine titration(24 hours)
- SOFA score(Up to 4 weeks.)
研究者
Mai Salah Salem
Assistant lecturer
Tanta University