Trauma Exposure and Suicidal Behaviors in Adolescents Aged 11-17 Hospitalized in Child and Adolescent Psychiatry
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 120
- 主要终点
- CPC Questionnaire child version
研究概览
简要总结
It is a comparative monocentric study with longitudinal follow-up at 6 months in adolescents aged between 11 years and 17 years inclusive admitted to complete hospitalization either for suicidal behaviors or for other psychiatric causes. The objective is to explore the experiences of hospitalized adolescents regarding hospitalization, as well as their perceptions of the factors involved in their remission and their experience of the traumatic event(s) if they have been exposed.
详细描述
Suicidal behaviors among adolescents are a major public health issue. Traumatic exposure (sexual abuse, violence, serious accidents) is a recognized risk factor for psychopathology and suicidality, but its precise links with suicide recurrence, comorbid psychopathology, and neurodevelopmental vulnerability remain little studied.
Hypotheses:
- Traumatic exposure is more common among suicidal adolescents than non-suicidal.
- It is associated with an increased risk of recurrence within 6 months.
- The neurodevelopmental load, irritability, PTSD and lack of resilience factors modulate this risk.
- Specific inflammatory biological profiles could be associated with suicidality.
Originality and innovative aspects:
- Multidimensional approach: clinical, psychometric, biological and qualitative.
- Constitution of a biobank for future analyses (inflammatory, genetic, epigenetic).
- Inclusion of a qualitative component exploring the subjective experience of hospitalized adolescents.
- Integrated analysis of risk, protective and biological factors to guide personalized prevention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 11 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Common Inclusion Criteria:
- •Age between 11 and 17 years inclusive
- •Admitted for full-time psychiatric hospitalization
- •Obtaining consent from at least one of the adolescent's legal representatives and the adolescent's personal assent
- •Inclusion Criteria - "Suicidal Group":
- •- Reason for admission: suicidal behavior (suicide attempt)
- •Inclusion Criteria - "Non-Suicidal Group":
- •- Reason for admission: other psychiatric causes (including suicidal thoughts without suicide attempt and non-suicidal self-injurious behavior)
排除标准
- •- Neither parent available to participate in the intervention
- •Exclusion Criterion - "Non-Suicidal Group":
- •- History of suicidal behavior prior to the current hospitalization
研究组 & 干预措施
suicide group
adolescents aged between 11 years old and 17 years inclusive admitted to hospital for suicidal behaviors
干预措施: Blood samples (Biological)
suicide group
adolescents aged between 11 years old and 17 years inclusive admitted to hospital for suicidal behaviors
干预措施: genetic analysis (Genetic)
suicide group
adolescents aged between 11 years old and 17 years inclusive admitted to hospital for suicidal behaviors
干预措施: Questionnaires and scales (Other)
non-suicidal group
aged between 11 years old and 17 years inclusive admitted to hospital for other psychiatric causes without a history of suicidal behavior
干预措施: Blood samples (Biological)
non-suicidal group
aged between 11 years old and 17 years inclusive admitted to hospital for other psychiatric causes without a history of suicidal behavior
干预措施: genetic analysis (Genetic)
non-suicidal group
aged between 11 years old and 17 years inclusive admitted to hospital for other psychiatric causes without a history of suicidal behavior
干预措施: Questionnaires and scales (Other)
结局指标
主要结局
CPC Questionnaire child version
时间窗: Baseline
This questionnaire evaluates the symptoms of PTSD and their frequency in children aged 7 to 18 years, following a traumatic event. Completion time is 15-20 minutes and the total score can range from 0 (no symptoms) to 84 (maximum symptoms) for symptom intensity and from 0 (no functional impact) to 24 (maximum functional impact) for functional impairment. The scale will be administered by a clinician (psychologist or psychiatrist for children and adolescents).
次要结局
- CPC questionnaire parents version(Baseline)
- Questionnaire Life Event Checklist (LEC-5)(Baseline)
- Schedule for Affective Disorders and Schizophrenia for school-age children (KSADS) full-life version(Baseline)
- Post-traumatic Stress Disorder Checklist for DSM-5 (PCL-5)(Baseline)
- Affective Reactivity Index (ARI)(Baseline)
- Child Youth Resilience Measure (CYRM)(Baseline)
- Adverse Childhood Experiences International Questionnaire (ACE-IQ)(Baseline)
- CER-Q(Baseline)
- BRIEF-2(Baseline)
- Meta-Cognitions Questionnaire for Adolescents (MCQ-A)(Baseline)
- DES-A(Baseline)
- Neurodevelopmental score(Baseline)
- Screen time(Baseline)
- Perinatal history : parental psychiatric disorders(Baseline)
- Perinatal history : parental age at birth(Baseline)
- Perinatal history : perinatal complications(Baseline)
- Collection of suicidal behavior(6 months)