The Effects of 6-month Supplementation With Creatine and Guanidinoacetic Acid on Biomarkers of Sarcopenia in Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in muscular strength
研究概览
简要总结
Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. Among potential therapeutic candidates, guanidinoacetate (GAA) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. Interestingly, GAA-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. Here, we plan to evaluate does creatine-GAA supplementation affects various biomarkers of sarcopenia in elderly.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 70 years
- •Free of acute disorders
排除标准
- •History of dietary supplement use during the past 4 weeks
研究组 & 干预措施
Creatine-guanidinoacetic acid
2 grams of creatine and 2 grams of GAA Administered one dose two times per day on an empty stomach in the morning and at the evening
干预措施: Creatine-guanidinoacetic acid (Dietary Supplement)
Inulin
4 grams of inulin Administered one dose two times per day on an empty stomach in the morning and at the evening
干预措施: Inulin (Other)
结局指标
主要结局
Change in muscular strength
时间窗: Baseline vs. 6 months post-intervention
Baseline vs. 6 months
次要结局
- Change in muscle mass(Baseline vs. 6 months post-intervention)
- Change in cognitive performance evaluated with Mini-Mental State Exam test(Baseline vs. 6 months post-intervention)
- Change in muscle metabolites evaluated with MR spectroscopy(Baseline vs. 6 months post-intervention)
- Change in serum creatine(Baseline vs. 6 months post-intervention)