Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Index of Microcirculatory Resistance (IMR)
研究概览
简要总结
When performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation. The gold standard for this evaluation is Fractional Flow Reserve (FFR). FFR is a flow ratio transformed into a pressure ratio by simplification, neglecting some parameters, especially microcirculatory resistance.
The aim of this study is to investigate hemodynamic and structural assessment induced in specific conditions, and their repercussion on functional assessment by FFR to implement the diagnostic approach and personalize it for each patient.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intermediate coronary lesion (between 50 and 70%)
排除标准
- •Hemodynamic instability
- •Adenosine hypersensitivity
- •Severe chronic obstructive pulmonary disease
- •Wolff parkinson white
- •High degree atriovenricular block
- •Left-right shunt
- •Carotid artery stenosis with hemodynamic insufficiency
- •Pregnancy
结局指标
主要结局
Index of Microcirculatory Resistance (IMR)
时间窗: During coronary angiography
IMR = Pd x Tmn at maximal hyperhemia Normal range \< 25
次要结局
- Quantitative Flow Ratio (QFR)(During coronary angiography)
- Death(12 months)
- Fractional Flow Reserve (FFR)(During coronary angiography)
- Resting Full cycle Ratio (RFR)(During coronary angiography)
- Coronary Flow Reserve (CFR)(During coronary angiography)
- Angio-IMR(During coronary angiography)
- Angina pectoris (CCS)(12 months)