NCT07037706已完成不适用
Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study
Centre Hospitalier de Saint-Denis1 个研究点 分布在 1 个国家目标入组 250 人开始时间: 2023年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Duration of mechanical ventilation (in days) among patients with ACS treated with empiric macrolides
研究概览
简要总结
This study looks at whether using macrolide antibiotics is helpful and safe in treating acute chest syndrome, a serious complication in people with sickle cell disease. It reviews past cases from three hospitals where patients were treated in intensive care. The goal is to understand if macrolides make a difference, what germs are involved, how useful lab tests are, and how well patients tolerate these antibiotics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient (≥18 years old).
- •Diagnosis of acute chest syndrome (ACS).
- •Hospitalized in an intensive care unit (ICU).
- •Microbiological sampling performed (e.g., multiplex PCR, sputum culture [ECBC], and/or Legionella urinary antigen test).
- •Received empiric antibiotic therapy including a macrolide.
排除标准
- •Minor patient (<18 years old).
- •Acute chest syndrome not requiring ICU admission.
- •Acute chest syndrome without any attempt at microbiological documentation.
结局指标
主要结局
Duration of mechanical ventilation (in days) among patients with ACS treated with empiric macrolides
时间窗: 28 days
次要结局
未报告次要终点
研究者
研究点 (1)
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