The effect of prednisolone versus hydrocortisone as glucocorticoid replacement therapy on hypoglycaemia frequency in people with Type 1 diabetes and adrenal insufficiency: a pilot study. - Hypoglycaemia frequency in people with Type 1 diabetes and adrenal insufficiency.

King's College London0 个研究点目标入组 3 人开始时间: 2011年5月25日最近更新: 2019年6月30日

适应症

试验速览

暂无简介。

•1. Able to provide informed consent to participate in the study
•2. Age 18 or over
•3. Type 1 diabetes.
•4. On current insulin regimen for at least 4 weeks.
•5. Understanding of the principles of self-adjustment of insulin regimen on the basis of self blood glucose monitoring results.
•6. Adrenal insufficiency
•7. On current hydrocortisone regimen for at least 2 months.
•8. Normal thyroid function or on appropriate thyroxine replacement.
•9. With or without problematic hypoglycaemia.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 16
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 16

•1. Inability to give informed consent
•2. Age less than 18 years
•3. Pregnancy or breastfeeding
•4. Currently enrolled in other clinical study
•5. Islet transplant / pancreatic transplant
•6. Other steroid treatment (except inhalers and topical steroids)
•7. Unstable angina, myocardial infarction, uncontrolled congestive cardiac failure in the previous year
•8. Recent history of cancer (<5years)
•9. Chronic kidney disease ( stage 3-5)
•10. Liver function tests more than 3 times the upper limit of normal.
•11. Coagulopathy (INR>1.5 or platelets less than 50x109/L)
•12. Anaemia (Hb less than 10g/dL, except stable haemoglobinopathy)

发起方