Quadriceps neuromuscular electrical stimultaion (NMES) as an adjunct to pulmonary rehabilitation in patients with COPD and quadriceps weakness - a randomised double-blind placebo-controlled trial

Royal Brompton & Harefield NHS Foundation Trust0 个研究点目标入组 108 人开始时间: 2017年12月14日最近更新: 2019年10月29日

适应症

试验速览

暂无简介。

•1. Aged =40 years
•2. Confirmed diagnosis of COPD according to GOLD guidelines
•3. Referred for outpatient PR
•4. Quadriceps muscle weakness defined as quadriceps maximum voluntary contraction (QMVC, kg) / Body Mass Index (BMI, kg/m2) ratio =1.2
•5. Able to provide written informed consent

•1. Any condition that precludes providing informed consent e.g. cognitive impairment or inadequate English
•2. Participation in an exclusively home-based pulmonary rehabilitation programme
•3. Predominant neuromuscular or joint limitation to walking or cycling
•4. Co-existing progressive neurological or neuromuscular condition
•5. Contraindication for unsupervised use of NMES including pregnancy, implanted cardiac pacemaker, skin abrasion, metallic lower limb prosthesis
•6. Formal supervised pulmonary rehabilitation in the preceding six months
•7. Unstable cardiac conditions including unstable angina, unstable congestive heart failure, severe aortic stenosis, suspected aortic aneurysm
•8. Active or suspected thromboembolic disease including recent pulmonary embolism
•9. An acute exacerbation requiring antibiotics within the preceding four weeks

发起方