TROG12.01 A Randomised Trial of Weekly Cetuximab and Radiation Versus Weekly Cisplatin and Radiation in Good Prognosis Locoregionally Advanced HPV-Associated Oropharyngeal Squamous Cell Carcinoma
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 189
- 试验地点
- 16
- 主要终点
- Symptom Severity
研究概览
简要总结
A standard treatment for patients with head and neck cancer is radiation given with high doses of a chemotherapy drug called cisplatin, given every 3 weeks during the radiation. This treatment is effective but can significantly increase side effects such as difficulty with swallowing, a sore mouth, fatigue, hearing loss, ringing in the ears and kidney failure. In Australia, a commonly used treatment HPV-Associated Oropharyngeal Squamous Cell Carcinoma is a lower dose of cisplatin given weekly during the radiation. The high dose and low dose schedules result in a similar total dose of cisplatin being given during the radiation, but it is thought that the weekly schedule results in fewer side effects while maintaining effectiveness.
Another approach widely used around the world for patients with head and neck cancer, is to administer the antibody, cetuximab, weekly during radiation. Cetuximab has a very different side effect profile to cisplatin, and has been reported to result in less exacerbation of radiation related side effects. Both cetuximab and cisplatin can reduce the growth of a cancer and increase the effectiveness of radiation. Both cisplatin and cetuximab appear to be effective treatments in combination with radiation, but have not been directly compared.
The purpose of this study is to compare the treatment related side effects (both acute and longer term) between the cisplatin and cetuximab regimens. Both treatments would be given with the same dose of radiation therapy over 7 weeks. The results of this trial will help determine the optimal treatment for patients with HPV-Associated Oropharyngeal Squamous Cell Carcinoma.
详细描述
Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence and has an improved prognosis compared to other head and neck malignancies when treated with standard combination chemoradiation.
The current standard regimen of high dose cisplatin and Radiation Therapy (RT) for head and neck cancer patients results in significant toxicity and is at the limits of tolerance. The excellent prognosis of patients with HPV-positive OPSCC raises concerns about overtreatment with the current standard of care, resulting in unnecessary acute and late morbidity.
Therefore, investigation of chemo-sparing or chemo-modified regimens with RT for HPV-associated OPSCC that do not compromise efficacy is warranted. A number of regimens less intensive than high dose cisplatin are being used in clinical practice for patients with good prognosis HPV OPSCC, but no comparative trials have been performed in this population. The trial population will be restricted to low risk HPV-associated OPSCC.
Trial Arms:
A- RT (70 Gy in 35 fractions, 5 days a week over 7 weeks) with weekly Cetuximab (400 mg/m2 loading dose IV prior to radiation, followed by weekly cetuximab 250 mg/m2 for the duration of the radiotherapy) B- RT(70 Gy in 35 fractions, 5 days a week over 7 weeks) with weekly Cisplatin (40 mg/m2 IV for the duration of the radiotherapy)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years or older
- •Has provided written Informed Consent for participation in this trial
- •Histologically confirmed squamous cell carcinoma of the oropharynx with p16 positive status confirmed locally by immunohistochemistry
- •Stage III (excluding T1-2N1) or stage IV (excluding T4, N3, and distant metastasis) if smoking history of < /=10 pack years. If > 10 pack years nodal disease must be N0 - N2a.
- •If an excisional biopsy has been performed, patients remain eligible for the study provided there is clinically measurable disease prior to commencing RT. The residual disease should still meet the stage criteria required for the trial e.g. excisional biopsy of a node with residual T3 primary, or tonsillectomy for T1 primary with residual > N2a nodes.
- •No prior treatment for oropharyngeal cancer
- •Adequate haematological, renal, and hepatic function as defined by,
- •Absolute neutrophil count (ANC, segs + bands) > /= 1.5 x 109/L
- •Platelet count > /= 100 x 109/L
- •Total bilirubin < /= 1.5 x upper normal limit
- •ALT < /= 2.5 x upper normal limit
- •Calculated creatinine clearance (Cockcroft-Gault formula) or isotopic GFR > 55ml/min
- •ECOG performance status score of 0-1
- •Participants capable of childbearing are using adequate contraception and intend to continue use of contraception for at least 6 months following completion of treatment
- •Negative pregnancy test within 72 hours prior to randomisation of women who are of childbearing potential
- •Suitable for follow-up for at least 24 months as per trial protocol.
- •Sufficient proficiency in English, cognitive capacity and willingness to complete questionnaires
排除标准
- •History of unknown primary of the head and neck
- •T4, N3 or distant metastases
- •Smoking history >10 pack years with N2b or c nodal status
- •Women who are pregnant or lactating.
- •Previous radiotherapy to the area to be treated (excluding superficial radiotherapy for a cutaneous malignancy)
- •Previous cisplatin or carboplatin chemotherapy
- •Prior EGFR targeted therapy of any kind
- •Primary surgery to the affected area (excisional biopsy allowed)
- •Peripheral neuropathy > /= grade 2 (CTCAE v4.0)
- •Sensori-neural hearing impairment >= grade 2 (CTCAE v4.0, hearing impaired, not enrolled on a monitoring program) which may be exacerbated by cisplatin (Audiometric abnormalities without corresponding clinical deafness will not be grounds for exclusion)
- •Tinnitus > /= grade 2 (CTCAE v4.0)
- •History of interstitial lung disease or evidence of interstitial lung disease on pre-registration CT
- •History of myocardial infarction within 12 months prior to study entry, uncontrolled congestive heart failure, unstable angina, active cardiomyopathy, unstable arrhythmia, uncontrolled psychotic disorders, active serious infections, active peptic ulcer disease, immunosuppression due to post-organ transplantation or use of immunosuppressants for autoimmune disorders
- •Patients known to be HIV positive
- •Other cancer that was diagnosed:
- •more than 5 years prior to current diagnosis with (i) subsequent evidence of disease recurrence or (ii) clinical expectation of recurrence is greater than 10% or
- •within 5 years of the current diagnosis, with the exception of successfully treated basal cell or squamous cell skin carcinoma, in situ melanoma, or carcinoma in situ of the cervix
研究组 & 干预措施
Radiation Therapy + Cetuximab
RT (70 Gy in 35 fractions, 5 days a week over 7 weeks) with weekly Cetuximab (400 mg/m2 loading dose IV prior to radiation, followed by weekly cetuximab 250 mg/m2 for the duration of the radiotherapy)
干预措施: Cetuximab (Drug)
Radiation Therapy + Cetuximab
RT (70 Gy in 35 fractions, 5 days a week over 7 weeks) with weekly Cetuximab (400 mg/m2 loading dose IV prior to radiation, followed by weekly cetuximab 250 mg/m2 for the duration of the radiotherapy)
干预措施: RT (70 Gy in 35 fractions) (Radiation)
Radiation Therapy + Cisplatin
RT(70 Gy in 35 fractions, 5 days a week over 7 weeks) with weekly Cisplatin (40 mg/m2 IV for the duration of the radiotherapy)
干预措施: RT (70 Gy in 35 fractions) (Radiation)
Radiation Therapy + Cisplatin
RT(70 Gy in 35 fractions, 5 days a week over 7 weeks) with weekly Cisplatin (40 mg/m2 IV for the duration of the radiotherapy)
干预措施: Cisplatin (Drug)
结局指标
主要结局
Symptom Severity
时间窗: 20 weeks
The area under curve of symptom severity between weekly cisplatin and Radiotherapy Therapy (RT) versus weekly cetuximab and RT from baseline to week 20 (13 weeks post-completion of radiotherapy) as measured by M.D. Anderson Symptom Inventory - Head and Neck Module (MDASI-HN).
次要结局
- Symptom severity(24 months)
- Interference of symptoms with daily life(24 mths)
- Psychological distress(36 months)
- Impact on Health Related Quality of Life(36 months)
- Speech and dietary function(36 months)
- Hearing impairment(24 months)
- Overall survival(60 months)
- Cost of health resource utilisation(24 months)
- Swallowing dysfunction(12 months)
- Rate of enteral feeding(12 months)
- Failure-free survival(36 months)
- Pattern of disease failure(36 months)
- Complete response rate(20 weeks)
- Clinician-assessed acute and late toxicity(60 months)
- Time to locoregional failure(36 months)
- Work status and time to return to work(24 months)
- Potential prognostic markers(60 months)