Effect of two different levels of positive end expiratory pressure PEEP on oxygenation and ventilation during pneumoperitoneum for laparoscopic surgery in adults A randomized controlled study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- To compare effect of two different levels of positive end-expiratory pressure levels (PEEP) on oxygenation during pneumoperitoneum for laparoscopic surgery in adults by doing arterial blood gas analysis
研究概览
简要总结
patients are randomly allocated into 2 groups based on peep levels.group A receives low peep 5 and group B receives high peep 10.all patients undergo volume controlled ventilation with low tidal volume,standardised fio2 and fixed peep during pneumoperitoneum.ventilation settings incude I E ratio 1:1,peak pressure less than 16 cm h2o,RR adjusted for normocapnia.anaesthesia induction maintenance ,muscle relaxation and analgesia follow normal institutional protocol.haemodynamic,respiratory parameters and ABG value are recorded at base;line,during pneumoperitoneum and postoperatively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade I and II.
- •Duration of surgery expected to exceed 60 minutes.
- •BMI between 18.5 and 30 kg/m2.
排除标准
- •Patients with history of significant pulmonary diseases (Eg:COPD, ASTHMA, RESTRICTIVE LUNG DISEASES).
- •Patients with neuromuscular disorders or chest wall deformities.
- •Pregnant women and lactating mothers.
- •Known or suspected cardiovascular instability or heart failure.
结局指标
主要结局
To compare effect of two different levels of positive end-expiratory pressure levels (PEEP) on oxygenation during pneumoperitoneum for laparoscopic surgery in adults by doing arterial blood gas analysis
时间窗: T1- Baseline (post-induction). | T2- Five minutes after pneumoperitoneum. T3-One hour after application of PEEP during pneumoperitoneum. | T4-After desufflation
次要结局
- 1- To assess ventilation & hemodynamic changes associated with different levels of PEEP during laparoscopic surgery(Arterial Blood Gas (ABG) Analysis:)
研究者
DR NIKHIL MARTUR
Shri B.M Patil Medical College Hospital and Research Centre