跳至主要内容
临床试验/NCT07104578
NCT07104578招募中不适用

Evaluation of the Impact of Pleuropulmonary Ultrasound Performed by the Emergency Physician on the Diagnosis of Dyspnea in the Prehospital Setting

University Hospital, Toulouse1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年8月1日最近更新:

试验速览

阶段
不适用
状态
招募中
入组人数
40
试验地点
1
主要终点
Evaluation of the impact of pre-hospital EPP on the rate of appropriate treatments offered.

研究概览

简要总结

Dyspnea is a subjective symptom perceived by the patient as a sensation of "breathing discomfort", "suffocation", "lack of air" or "difficulty inhaling or exhaling". It is a frequent reason for calling for help (8% of calls). The most seriously ill patients require the dispatch of specialized teams capable of initiating respiratory support in order to reduce the morbidity and mortality of these patients. In France, these teams are medicalized by an emergency physician within the Mobile Emergency Resuscitation Services (SMUR). This is only rarely the case outside France, where specialized paramedical teams ("advanced life support paramedic teams") can be dispatched. Apart from their role of initiating possible respiratory support, these teams (SMUR or paramedics) can initiate a diagnostic approach and therapeutics related to the suspected origin of dyspnea. However, there are many diagnoses that can cause dyspnea, and the diagnostic process can be complex. The most common diagnoses described in the prehospital population are: bacterial pneumonia, acute heart failure, and exacerbation of COPD or asthma or pulmonary embolism. Each of these diagnoses requires specific drug treatment, guided by international recommendations. Inappropriate treatment of these pathologies (overtreatment or undertreatment) is common and associated with excess intrahospital mortality.

Pleuropulmonary ultrasound (PUS) has shown very interesting diagnostic performance in the intrahospital setting for diagnoses of interest in dyspnea. This performance also appears good in the prehospital setting. In the intrahospital setting, PUS appears to improve the diagnostic approach and appropriate treatments for dyspnea. In the prehospital setting, however, data on this subject are scarce or of limited quality according to the most recent meta-analysis, while the use of this technique is becoming increasingly common in standardized patient care. In addition, the most recent work on the subject included patients in a non-medicalized prehospital system. The use of PUS would allow paramedics to increase the rate of appropriate treatment from 14% to 53%. However, the rate of appropriate treatment expected by a medicalized team is expected to be 62%, and the diagnostic performance of physicians in PUS is probably higher than that of paramedics. These data must therefore be consolidated in a French system before being the subject of higher-level recommendations. The systematic use of PUS during prehospital engagement of a SMUR for dyspnea also may improves the rate of appropriate treatment, even in a context of medicalization of the initial care of patients.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patient
  • Treated by a prehospital emergency medical service
  • For dyspnea with signs of severity, the following are the following:
  • SpO2 < 90% in AA or O2 required to maintain SpO2 ≥ 90% and
  • RR > 25 cycles/min

排除标准

  • Opposition to inclusion
  • Need for immediate intubation.

结局指标

主要结局

Evaluation of the impact of pre-hospital EPP on the rate of appropriate treatments offered.

时间窗: from the inclusion of the patient until the time he or she leaves the hospital, assessed up 52 weeks, whichever came first

Therapeutic adequacy at the final diagnosis before and after completion of the PUS. Therapeutic adequacy and inadequacy are defined based on the treatment proposed before and after completion of the PUS, compared to the final diagnosis at hospital discharge. The following are considered inadequate: * In a patient on a pulmonary embolism (PE): * Prescribing beta-agonists or antibiotics (unless septic) * Not prescribing diuretics and nitrates if SBP \> 140 mmHg * In a patient with decompensated COPD: * Prescribing diuretics * Not prescribing beta-agonists * In a patient with a pulmonary infection: * Prescribing diuretics * Not prescribing antibiotics * In a patient with a pulmonary embolism: * Not prescribing curative doses of anticoagulation In the case of multiple diagnoses (e.g., transfer to a PE due to pneumonia), only treatments that are inadequate for each diagnosis will be considered inadequate.

次要结局

  • Evaluation of the impact of PUS carried out in prehospital settings on the diagnostic process.(from the inclusion of the patient until the time he or she leaves the hospital, assessed up 52 weeks, whichever came first)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验